Actinogen Medical Ltd
Actinogen Medical Limited is an Australia-based biotechnology company.
The business
Actinogen Medical Limited is an Australia-based biotechnology company. The Company is engaged in the development of a therapy for neurological and neuropsychiatric diseases associated with dysregulated brain cortisol. The Company is engaged in the development of its lead compound, Xanamem, as a therapy for Alzheimer’s Disease, Major Depressive Disorder, Fragile X Syndrome, and other neurological diseases where reducing cortisol inside brain cells could have a positive impact. Xanamem’s mechanism is to control elevated levels of cortisol (stress hormone) in the brain through the inhibition of the cortisol synthesis enzyme, 11B-HSD1, without affecting production of cortisol by the adrenal glands, which is essential for the body’s normal functioning. Xanamem is a once-a-day pill designed to deliver high levels of cortisol control in key areas of the brain related to Alzheimer’s and other diseases such as the hippocampus and frontal cortex.
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Latest news
Actinogen Medical’s Xanamem shows promising results in depression treatment trials
Australian biotechnology company Actinogen Medical (ASX: ACW) has received further positive analysis from studies of its Xanamem treatment for symptoms of depression. The consistent benefits observed in the XanaCIDD phase 2a depression trial data support the conclusion that a 10 milligram Xanamem dose is clinically active in controlling brain cortisol and has clinically-significant anti-depressant activity. […]
Market wrap: inflation pushes share prices lower on last trading day of the financial year
Inflation was the word on everybody’s lips as they dumped shares on the last trading day of the financial year but it was the price of goods and services rather than shares that had caught their attention. The week’s stunning news that inflation had reared back up to 4% for the year to May brought […]
Actinogen’s Xanamem could slow Alzheimer’s progress, new biomarker trial reveals
A biomarker trial of Actinogen Medical’s (ASX: ACW) lead candidate Xanamem has been published in the peer-reviewed Journal of Alzheimer’s Disease, with results showing the drug has the potential to slow disease progression in patients with elevated levels of phosphorylated tau (pTau). The trial comprised 72 participants from Actinogen’s previous XanADu Phase 2a trial who […]
Actinogen Medical launches Alzheimer’s trial to test impact of Xanamem on cognitive health
Actinogen Medical (ASX: ACW) has treated the first subject in its clinical trial of patients with biomarker-positive mild to moderate Alzheimer’s disease. The XanaMIA Phase 2b trial involves 220 participants with elevated levels of the blood biomarker pTau and measures the effects of a Xanamem 10mg daily dose versus placebo over a 36-week treatment period. […]
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